Indication

CHANTIX is a prescription medication that, along with support, helps adults 18 and over stop smoking. You may benefit from quit-smoking support programs and/or counseling during your quit attempt. It's possible that you might slip up and smoke while taking CHANTIX. If you do, you can stay on CHANTIX and keep trying to quit.
For Healthcare Professionals

Common Questions | CHANTIX® (varenicline) | Safety Info

Quitting with CHANTIX

What is CHANTIX?
CHANTIX is a nicotine-free pill that along with support, helps adults 18 and over quit smoking. It is a prescription medicine, so only a doctor can prescribe it. Depending on your quit approach, you take it for 12 or 24 weeks (3 or 6 months).
How is CHANTIX different?
CHANTIX is a nicotine-free pill. Nicotine replacement therapies (NRTs) like the patch, gum, lozenges, nasal spray, and inhalers contain nicotine. Talk to your doctor about the differences between CHANTIX and NRTs and which smoking cessation aid may be right for you. See how CHANTIX works.
Can I take CHANTIX with nicotine replacement therapies?
It is not known if CHANTIX is safe and effective when used with other stop smoking medicines. You should not use CHANTIX while using other medicines to stop smoking. Tell your doctor if you use other treatments to quit smoking. Talk to your doctor to learn more about how to quit smoking.
How long will I be able to smoke when I take CHANTIX?

After you start taking CHANTIX, you can smoke up until your quit date. There are 3 ways to take CHANTIX to help you quit.

When taking CHANTIX, you can choose a quit date in a week or up to a month after starting CHANTIX. Or, if you're sure you're not willing or able to quit that abruptly, you start CHANTIX and then cut your smoking in half each month with the goal of quitting at the end of 12 weeks (3 months), or sooner. Learn more about the 3 quit approaches.

What’s in CHANTIX?
Active ingredient: varenicline tartrate. Inactive ingredients: microcrystalline cellulose (NF), anhydrous dibasic calcium phosphate (USP), croscarmellose sodium (NF), colloidal silicon dioxide (NF), magnesium stearate (NF), Opadry® White (for 0.5 mg), Opadry® Blue (for 1 mg), and Opadry® Clear (for both 0.5 mg and 1 mg).

Talking to your doctor

How do I get CHANTIX?
CHANTIX is only available by prescription, so you must speak to your doctor to get a prescription. Talk to your doctor or connect with one today about whether CHANTIX or another quit-smoking treatment may be right for you.
What should I tell my doctor before starting CHANTIX?

Some people have had serious side effects while using CHANTIX to help them quit smoking including:

New or worse mental health problems, such as changes in behavior, hostility, agitation, depressed mood, and suicidal thoughts or actions. Some people had these symptoms when they began taking CHANTIX, and others developed them after several weeks of treatment, or after stopping CHANTIX.

Before taking CHANTIX, tell your doctor if you have ever had depression or other mental health problems. You should also tell your doctor about any symptoms you had during other times you tried to quit smoking, with or without CHANTIX.

Stop taking CHANTIX and call your doctor right away if you, your family, or caregiver notice agitation, hostility, depression or changes in your behavior or thinking that are not typical for you, or you develop any of the following symptoms:

  • Thoughts about suicide or dying, or attempts to commit suicide
  • New or worse depression, anxiety or panic attacks
  • Feeling very agitated or restless
  • Acting aggressive, being angry, or violent
  • Acting on dangerous impulses
  • An extreme increase in activity and talking (mania)
  • Abnormal thoughts or sensations
  • Seeing or hearing things that are not there (hallucinations)
  • Feeling people are against you (paranoia)
  • Feeling confused
  • Other unusual changes in behavior or mood

When you try to quit smoking, with or without CHANTIX, you may have symptoms that may be due to nicotine withdrawal, including urge to smoke, depressed mood, trouble sleeping, irritability, frustration, anger, feeling anxious, difficulty concentrating, restlessness, decreased heart rate, and increased appetite or weight gain. Some people have even experienced suicidal thoughts when trying to quit smoking without medication. Sometimes quitting smoking can lead to worsening of mental health problems that you already have, such as depression.

Before you take CHANTIX, tell your doctor if you:

  • Use other treatments to quit smoking. Using CHANTIX with a nicotine patch may cause nausea, vomiting, headache, dizziness, upset stomach, and tiredness to happen more often than if you just use a nicotine patch alone.
  • Have kidney problems or get kidney dialysis. Your doctor may prescribe a lower dose of CHANTIX for you.
  • Have a history of seizures
  • Drink alcohol
  • Have heart or blood vessel problems
  • Have any other medical conditions
  • Are pregnant or plan to become pregnant. It is not known if CHANTIX will harm your unborn baby.
  • Are breastfeeding. It is not known if CHANTIX passes into breast milk. If you breastfeed and take CHANTIX, monitor your baby for seizures as well as spitting up or vomiting more than normal.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Your doctor may need to change the dose of some of your medicines when you stop smoking.

You should not use CHANTIX while using other medicines to quit smoking. Tell your doctor if you use other treatments to quit smoking.

Know the medicines you take. Keep a list of them with you to show your doctor and pharmacist when you get a new medicine.

For help starting the conversation with your doctor, click here.

When should I plan to QUIT SMOKING WHEN TAKING CHANTIX?

There are 3 ways to use CHANTIX to help you quit smoking. Depending on your quit approach, your quit date could be a week or up to a month after starting CHANTIX. Or, if you're sure you're not willing or able to quit that abruptly, you start CHANTIX and then cut your smoking in half each month with the goal of quitting at the end of 12 weeks (3 months), or sooner. Learn more about the 3 quit approaches.

Why should I quit smoking?

There are many health benefits of quitting smoking, starting on day 1.

  • 20 Minutes After Quitting
    Your heart rate may drop
  • 12 Hours After Quitting
    Carbon monoxide levels in the blood may return to normal
  • 2 Weeks to 3 Months
    After Quitting
    Heart attack risk can begin to drop and lung function can begin to improve
  • 1 to 9 Months After Quitting
    Your coughing and shortness of breath may decrease
  • 1 Year After Quitting
    Your added risk of coronary heart disease is half that of a smoker's
  • 2 to 5 Years After Quitting
    Your risk of having a stroke is reduced to that of a nonsmoker's, and within 5 years your risk of cancers of the mouth, throat, esophagus and bladder is halved
  • 10 Years After Quitting
    Your risk of dying from lung cancer is about half that of a smoker's and your risk of cancer of the kidney and pancreas decreases
  • 15 Years After Quitting
    Your risk of coronary heart disease is the same as that of
    a nonsmoker’s

To find more information about nicotine addiction and the benefits of quitting, visit the Resources page.

Can e-cigarettes help me quit smoking?
While some people may use them to replace cigarettes or in addition to smoking, e-cigarettes are not FDA-approved as an option to help you quit. The benefits and risks of using e-cigarettes are not known. Talk to your doctor or connect with one today to learn more.

CHANTIX has not been studied in patients using e-cigarettes and is not indicated for use in these patients.

Potential side effects

What is the most important information I should know about CHANTIX?

Some people have had serious side effects while using CHANTIX to help them quit smoking, including:

New or worse mental health problems, such as changes in behavior, hostility, agitation, depressed mood, and suicidal thoughts or actions. Some people had these symptoms when they began taking CHANTIX, and others developed them after several weeks of treatment, or after stopping CHANTIX.

Before taking CHANTIX, tell your doctor if you have ever had depression or other mental health problems. You should also tell your doctor about any symptoms you had during other times you tried to quit smoking, with or without CHANTIX.

Stop taking CHANTIX and call your doctor right away if you, your family, or caregiver notice agitation, hostility, depression or changes in your behavior or thinking that are not typical for you, or you develop any of the following symptoms:

  • Thoughts about suicide or dying, or attempts to commit suicide
  • New or worse depression, anxiety, or panic attacks
  • Feeling very agitated or restless
  • Acting aggressive, being angry, or violent
  • Acting on dangerous impulses
  • An extreme increase in activity and talking (mania)
  • Abnormal thoughts or sensations
  • Seeing or hearing things that are not there (hallucinations)
  • Feeling people are against you (paranoia)
  • Feeling confused
  • Other unusual changes in behavior or mood

When you try to quit smoking, with or without CHANTIX, you may have symptoms that may be due to nicotine withdrawal, including urge to smoke, depressed mood, trouble sleeping, irritability, frustration, anger, feeling anxious, difficulty concentrating, restlessness, decreased heart rate, and increased appetite or weight gain. Some people have even experienced suicidal thoughts when trying to quit smoking without medication. Sometimes quitting smoking can lead to worsening of mental health problems that you already have, such as depression.

What should I avoid while taking CHANTIX?

  • Use caution when driving or operating machinery until you know how CHANTIX affects you. CHANTIX may make you feel sleepy, dizzy, or have trouble concentrating, making it hard to drive or perform other activities safely.
  • Decrease the amount of alcoholic beverages that you drink during treatment with CHANTIX until you know if CHANTIX affects your ability to tolerate alcohol. Some people have experienced the following when drinking alcohol during treatment with CHANTIX:

    • increased drunkenness (intoxication)
    • unusual or sometimes aggressive behavior
    • no memory of things that have happened
What are the possible side effects of CHANTIX?

Some people have had serious side effects while using CHANTIX to help them quit smoking, including:

New or worse mental health problems, such as changes in behavior, hostility, agitation, depressed mood, and suicidal thoughts or actions. Some people had these symptoms when they began taking CHANTIX, and others developed them after several weeks of treatment, or after stopping CHANTIX.

Before taking CHANTIX, tell your doctor if you have ever had depression or other mental health problems. You should also tell your doctor about any symptoms you had during other times you tried to quit smoking, with or without CHANTIX.

Stop taking CHANTIX and call your doctor right away if you, your family, or caregiver notice agitation, hostility, depression or changes in your behavior or thinking that are not typical for you, or you develop any of the following symptoms:

  • Thoughts about suicide or dying, or attempts to commit suicide
  • New or worse depression, anxiety, or panic attacks
  • Feeling very agitated or restless
  • Acting aggressive, being angry, or violent
  • Acting on dangerous impulses
  • An extreme increase in activity and talking (mania)
  • Abnormal thoughts or sensations
  • Seeing or hearing things that are not there (hallucinations)
  • Feeling people are against you (paranoia)
  • Feeling confused
  • Other unusual changes in behavior or mood

When you try to quit smoking, with or without CHANTIX, you may have symptoms that may be due to nicotine withdrawal, including urge to smoke, depressed mood, trouble sleeping, irritability, frustration, anger, feeling anxious, difficulty concentrating, restlessness, decreased heart rate, and increased appetite or weight gain. Some people have even experienced suicidal thoughts when trying to quit smoking without medication. Sometimes quitting smoking can lead to worsening of mental health problems that you already have, such as depression.

Serious side effects of CHANTIX may include:

  • Seizures. Some people have had seizures during treatment with CHANTIX. In most cases, the seizures have happened during the first month of treatment with CHANTIX. If you have a seizure during treatment with CHANTIX, stop taking CHANTIX and contact your healthcare provider right away.
  • New or worse heart or blood vessel (cardiovascular) problems, mostly in people, who already have cardiovascular problems. Tell your doctor if you have any changes in symptoms during treatment with CHANTIX.

Get emergency medical help right away if you have any of the following symptoms of a heart attack, including:

  • Chest discomfort (uncomfortable pressure, squeezing, fullness or pain) that lasts more than a few minutes, or that goes away and comes back
  • Pain or discomfort in one or both arms, back, neck, jaw or stomach
  • Shortness of breath, sweating, nausea, vomiting, or feeling lightheaded associated with chest discomfort
  • Sleepwalking can happen with CHANTIX, and can sometimes lead to behavior that is harmful to you or other people, or to property. Stop taking CHANTIX and tell your doctor if you start sleepwalking.
  • Allergic reactions can happen with CHANTIX. Some of these allergic reactions can be life-threatening.
  • Serious skin reactions, including rash, swelling, redness, and peeling of the skin. Some of these skin reactions can become life-threatening.

Stop taking CHANTIX and get medical help right away if you have any of the following symptoms:

  • Swelling of the face, mouth (tongue, lips, and gums), throat or neck
  • Trouble breathing
  • Rash with peeling skin
  • Blisters in your mouth

The most common side effects of CHANTIX include:

  • Nausea
  • Sleep problems (trouble sleeping or vivid, unusual, or strange dreams)
  • Constipation
  • Gas
  • Vomiting

Tell your doctor about side effects that bother you or that do not go away.

These are not all the side effects of CHANTIX. Ask your doctor or pharmacist for more information.

What can I do if I feel nauseous?
Nausea is a common side effect of taking CHANTIX. Talk to your doctor if you are having side effects such as nausea. Your doctor may want to reduce your dose. Click here to learn more.
Who should not take CHANTIX?

Do not take CHANTIX if you have had a serious allergic or skin reaction to CHANTIX. Symptoms may include:

  • Swelling of the face, mouth (tongue, lips, gums), throat or neck
  • Trouble breathing
  • Rash, with peeling skin
  • Blisters in your mouth

Taking CHANTIX properly

How do I take CHANTIX?

CHANTIX should always be taken after eating, with a full glass (8 oz) of water. During the first week of CHANTIX, your dose will gradually increase.

CHANTIX dosing at a glance*

Take 1 white pill (0.5 mg) daily

Take 1 white pill (0.5 mg) in the morning and 1 in the evening

Take 1 blue pill (1 mg) in the morning and 1 in the evening*

*This dosing schedule may not be right for everyone—talk with your doctor.

Most people will take CHANTIX for 12 weeks (3 months). If you have completely quit smoking by the end of 12 weeks, your doctor may prescribe CHANTIX for another 12 weeks to help you stay smokefree. Or, if you and your doctor decide that the Gradual Quit Approach is right for you, you will take CHANTIX for a total of 24 weeks.

Watch a video to learn more about getting started with CHANTIX.

What if I miss a dose of CHANTIX?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose. Just take your next regular dose.
What if I slip up and smoke while taking CHANTIX?
You should try to stop smoking on your quit date, but if you slip up and smoke, keep trying. Some people need to take CHANTIX for a few weeks for it to work best. Learn more about how you can stay on track with CHANTIX.
How long should I take CHANTIX?
Depending on the quit approach that you and your doctor choose, CHANTIX will be taken for 12 or 24 weeks (3 or 6 months).
What happens after taking CHANTIX for 12 weeks?

Most people will take CHANTIX for 12 weeks (3 months). If you have completely quit smoking by the end of 12 weeks, your doctor may prescribe CHANTIX for another 12 weeks to help you stay smokefree.

If you and your doctor decide that the Gradual Quit Approach is right for you, you will take CHANTIX for a total of 24 weeks.

What happens if I quit smoking before I finish my CHANTIX therapy?
You should take CHANTIX for the full 12 or 24 weeks (3 or 6 months), depending on the quit approach you and your doctor decide is right for you. Always take CHANTIX as prescribed.
Can I take CHANTIX again if I didn’t quit before?
If you are motivated to quit smoking and did not succeed during prior CHANTIX treatment for reasons other than side effects, or if you returned to smoking after treatment, speak to your doctor about whether another course of CHANTIX may be right for you.

Cost and support

What is GET QUIT®?

GET QUIT serves as a guide through your quit journey and provides you with the tools and resources you may need to stay inspired.

Here’s what you’ll get if you join GET QUIT:

  • Information on what to expect while taking CHANTIX
  • A personalized dashboard, at your fingertips, to help track your quit journey
  • Check-in emails with tips to help you through your toughest moments
  • Tips on how to manage behaviors related to smoking
How much does CHANTIX cost?
CHANTIX may be covered by many insurance plans. Cost may vary depending on your coverage. Call your health plan provider to find out more. Eligible patients may be able to save on CHANTIX. Learn more.
Can I save money on CHANTIX?

CHANTIX offers a savings card that eligible patients can use to save money on their monthly prescription of CHANTIX. Download a Savings Card to use when you fill your CHANTIX prescription at a participating pharmacy, and you may be able to save up to $75 per month (Terms and Conditions apply).

With the CHANTIX Savings Card:

  • If your out-of-pocket costs are $115 or less, you pay up to $40
  • If your out-of-pocket costs are more than $115, you save $75 off your costs

Offer can be used up to 6 times per calendar year.